Chemical Play
Always get full consent of others before doing chemical play.
Chroroform: Chloroform can cause internal organ damage including kidneys. NEVER DO THIS unless you are completely aware and consenting fully to the risk involved and with someone that you can trust with your life. Maximum Impact is some variation of this, they’re not good and have caused death.
Poppers (alkyl nitrites/ amyl nitrite): Poppers are used often to make one more relaxed, often used specifically for anal play. As with any play, make sure to check medical history. NEVER mix Popper with Viagra. Both of them will drop blood pressure into a lethal point.
Viagra/ Cialis: Well,, I’m sure you all know what they do XD. Check medical history of the other person involving low blood pressure/ high blood pressure. I know what I’m saying is rather contradictory since the use of these are very mainstream, but, most rescues I have done as a DM are due people fainting out due to popper viagra combination. A bottom reportedly took viagra and poppers because they want to impress the top when they got whipped (come on guys, that’s not the point).
As for any extreme play, you should have CPR/ First Aid certifications for this.